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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MAP2K6 All Species: 18.79
Human Site: T291 Identified Species: 34.44
UniProt: P52564 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P52564 NP_002749.2 334 37492 T291 S A E F V D F T S Q C L K K N
Chimpanzee Pan troglodytes Q9XT09 393 43428 V338 S L E F Q D F V N K C L I K N
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_851023 334 37590 T291 S E E F V D F T S Q C L K K N
Cat Felis silvestris
Mouse Mus musculus P70236 334 37414 T291 S A D F V D F T S Q C L K K N
Rat Rattus norvegicus Q4KSH7 419 47517 F356 F S G D F Q S F V K D C L T K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511595 352 40240 T307 S P E F V D F T A Q C L R K N
Chicken Gallus gallus Q90891 398 44059 V344 T Q D F Q E F V N K C L I K N
Frog Xenopus laevis Q07192 446 50082 T388 R E F S P S F T S F V N Q C L
Zebra Danio Brachydanio rerio Q9DGE0 361 40575 T318 S A D F V D F T S Q C L R K N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_477162 334 38176 I284 S P E F E D F I A V C L Q K E
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q20347 363 41178 F306 Y S L P L V K F I N T C L T K
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9S7U9 363 39830 I307 S P E L S S F I S T C L Q K D
Baker's Yeast Sacchar. cerevisiae P08018 668 72701 V600 S S D A Q D F V S L C L Q K I
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 32 N.A. 98.8 N.A. 97.9 38.6 N.A. 75.2 34.4 43.5 80.6 N.A. 58.6 N.A. 38.2 N.A.
Protein Similarity: 100 47.8 N.A. 99 N.A. 99 53.7 N.A. 85.5 51.5 56 85.8 N.A. 74.8 N.A. 56.2 N.A.
P-Site Identity: 100 60 N.A. 93.3 N.A. 93.3 0 N.A. 80 40 20 86.6 N.A. 53.3 N.A. 0 N.A.
P-Site Similarity: 100 73.3 N.A. 93.3 N.A. 100 13.3 N.A. 93.3 73.3 26.6 100 N.A. 66.6 N.A. 13.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 31.9 24.2 N.A.
Protein Similarity: N.A. N.A. N.A. 53.1 36 N.A.
P-Site Identity: N.A. N.A. N.A. 46.6 46.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 60 66.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 24 0 8 0 0 0 0 16 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 77 16 0 8 0 % C
% Asp: 0 0 31 8 0 62 0 0 0 0 8 0 0 0 8 % D
% Glu: 0 16 47 0 8 8 0 0 0 0 0 0 0 0 8 % E
% Phe: 8 0 8 62 8 0 85 16 0 8 0 0 0 0 0 % F
% Gly: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 16 8 0 0 0 16 0 8 % I
% Lys: 0 0 0 0 0 0 8 0 0 24 0 0 24 77 16 % K
% Leu: 0 8 8 8 8 0 0 0 0 8 0 77 16 0 8 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 16 8 0 8 0 0 54 % N
% Pro: 0 24 0 8 8 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 8 0 0 24 8 0 0 0 39 0 0 31 0 0 % Q
% Arg: 8 0 0 0 0 0 0 0 0 0 0 0 16 0 0 % R
% Ser: 70 24 0 8 8 16 8 0 54 0 0 0 0 0 0 % S
% Thr: 8 0 0 0 0 0 0 47 0 8 8 0 0 16 0 % T
% Val: 0 0 0 0 39 8 0 24 8 8 8 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _